YHOVN 2 năm trước

So sánh tác dụng giảm đau của thuốc mê giảm đau

Thuốc	Đường dùng	Khởi phát (min)	Đỉnh giảm đau (min)	Thời gian tác dụng (h)
Alfentanil	IM: 1 mg	IV: 1-2	IV: 1-2	IV: 0.25
Codeine	PO: 200 mg	PO: 30-45	PO: 60-120	PO: 4-6
Codeine	IM: 120 mg	IM:10-30	IM: 30-60	IM: 4
Fentanyl	IM: 0.1 mg	IV: <1	IV: 1-2	IV: 0.5-1
Fentanyl		IM: 7-5	IM: N/A	IM: 1-2
Hydromor- phone	PO: 7.5 mg	PO: 30	PO:90-120	PO: 4
	IM: 1.5 mg	IM:30-60	IM: 4-5
		IV: 10-15	IV: <20	IV: 2-3
Levorphanol	PO: 4 mg	PO: 10-60	PO: 90-120	PO: 4-5
	IM: 2 mg	IM: N/A	IM: 30-60	IM: 4-5
			IV: <20	IV: 4-5
Meperidine	PO: 300 mg	PO: 15	PO: 60-90	PO: 2-4
	IM: 75 mg	IM:10-15	IM: 60-120	IM: 2-4
		IV: 1	IV: 15-30	IV: 2-4
Methadone	PO: 20 mg	PO: 30-60	PO: 90-120	PO: 4-6^b
	IM: 10 mg	IM: 10-20	IM: 60-120	IM: 4-5^b
		IV: N/A	IV: 15-30	IV: 3-4^b
Morphine	PO: 60 mg	PO: 15-60	PO: 60-120	PO: 4-5
	IM: 10 mg	IM:10-30	IM: 30-60	IM: 4-5
		IV: <1	IV: 20	IV: 4-5
Oxycodone	PO: 30 mg	PO:15-30	PO: 60	PO: 4-6
Propoxyphene	Toxic^c	PO: 15-60	PO: 120	PO: 4-6
Remifentanil^d	IV: 0.05-0.15 mcg/kg	IV: <1	IV: <1	IV: 3-4 min
Sufentanil	IM: 0.01-0.02 mg	IV: <1	IV: 1-2	IV: 0.25-1
IM, intramuscular; IV, intravenous; PO,by mouth ^aDose in mg therapeutically equivalent to morphine 10 mg IM. IM doses are used to specify equivalent doses but are not recommended when IV access is available. ^bIncreases with repetitive dosing due to accumulation of drug and/or metabolites. ^cDose equivalent to 10 mg of morphine would be too toxic to administer. ^dRemifentanil is suitable for IV infusion only.